| Chemical Specifications | |
|---|---|
| Product Name | Botulinum Toxin Type A |
| CAS Number | 93384-43-1 |
| Molecular Formula | Complex Multi-chain Protein Complex |
| Molecular Weight | ~150 kDa (Core Toxin) to ~900 kDa (Complex) |
| Purity (HPLC) | ≥ 99.0% (Clinical/Research Grade) |
| Appearance | White Vacuum-Dried Lyophilized Powder |
| Storage | Store at 2°C to 8°C or -20°C (Strict Cold Chain Required) |
What is Botulinum Toxin Type A?
Botulinum Toxin Type A (100IU x 10 Vials Kit) is a highly purified, vacuum-dried neurotoxic protein complex derived from Clostridium botulinum. As a potent and reversible neuromuscular blocking agent, it temporarily inhibits the release of acetylcholine at the neuromuscular junction. This advanced formulation is the gold standard for researching and applying localized muscle relaxation, making it an indispensable tool in aesthetic medicine for long-lasting wrinkle reduction and in neurology for treating conditions like blepharospasm, cervical dystonia, and chronic migraine.
Key Features & Research Benefits
Anti-Wrinkle & Cosmetic King
The premier compound for non-surgical facial rejuvenation. It effectively smooths dynamic wrinkles (glabellar lines, crow’s feet, forehead lines) by temporarily relaxing the underlying hyperactive muscles, offering a youthful, refreshed appearance.
Neuromuscular Blockade
Exerts a highly specific, local effect on nerve endings, blocking cholinergic transmission. This targeted mechanism is crucial for studying and treating neurological disorders characterized by involuntary muscle contractions or spasms.
Hyperhidrosis Treatment
A highly effective intervention for severe primary axillary (underarm), palmar (hand), and plantar (foot) hyperhidrosis. It blocks the nerve signals that stimulate sweat glands, providing significant relief from excessive sweating.
Chronic Migraine Relief
Widely researched and utilized for prophylactic treatment of chronic migraines. In clinical models, targeted injections into specific head and neck muscle groups significantly reduce the frequency and severity of debilitating headache days.
Muscle Spasm Interference
Functions as a vital therapeutic tool for managing various forms of dystonia, upper limb spasticity, and strabismus. It effectively reduces muscle tone and rigidity, improving range of motion and reducing associated pain.
Vacuum-Dried for Stability
Supplied as a sterile, white vacuum-dried lyophilized powder to ensure maximum molecular stability and potency. This specific formulation requires strict cold chain storage (2-8°C) to maintain integrity for clinical or sensitive research use.
How It Works: Precision Neuro-Interference
Botulinum Toxin Type A operates through a sophisticated four-step cellular mechanism that results in a temporary and reversible chemical denervation of the target muscle.
Under normal conditions, nerves communicate with muscles by releasing a neurotransmitter called acetylcholine from vesicles inside the nerve ending into the synaptic cleft. Acetylcholine binds to receptors on the muscle fiber, triggering a contraction.
When Botulinum Toxin Type A is injected locally, the core 150 kDa neurotoxin molecule precisely identifies and binds with high affinity to specific receptors on the nerve terminal surface (Step 1: Binding). The toxin is then taken up into the nerve ending via an endocytic vesicle (Step 2: Internalization). Once inside, the light chain of the toxin is released into the cytosol (Step 3: Translocation). This light chain acts as a protease, specifically cleaving the SNAP-25 protein—a critical component of the SNARE protein complex required for acetylcholine vesicle fusion. By destroying SNAP-25, the vesicles are unable to fuse with the nerve membrane, completely blocking the release of acetylcholine (Step 4: Inhibition).
Without the acetylcholine signal, the muscle is unable to contract and enters a state of localized, flaccid paralysis. While the effect is powerful, it is not permanent. The body eventually regenerates new SNARE proteins and axonal sprouts form new synaptic connections, slowly restoring muscle function over several months.
🧪 What’s In The Kit
- Active Compound: Botulinum Toxin Type A
- Format: 10-Vial Research Kit
- State: Sterile, Vacuum-Dried Powder
- Net Contents: 100IU per vial (1000IU Total)
- Activity: Neuromuscular Blocking Agent
👩🔬 Who Uses It
- Aesthetic Dermatology Clinics
- Neurological Research Labs
- Migraine & Pain Management Centers
- Ophthalmology Researchers
- Sports Medicine Rehabilitation Labs
🔗 Best Paired With
- Sterile 0.9% Sodium Chloride (Non-preservative)
- Precision Tuberculin Syringes
- Ultra-Fine Needles (30G or 32G) 2-8°C Refrigerated Storage
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